Peptide Synthesis and Antigen Preparation Service

Protein antigen and peptide antigen can be used for the production of antibodies. The advantages of using peptide antigen when compared with protein antigen include its short preparation cycle, low cost, and easy modification.
Biologics International Corp (BIC) provides peptide antigen synthesis services. We have decades of experience in peptide design and synthesis, by which we can accurately predict peptide antigen epitopes and synthesize them quickly. In addition, using advanced equipment for peptide synthesis and purification including American Waters, Japanese Shimadzu HPLC, and automatic peptide synthesizer, we can provide high-quality peptide antigen for antibody production. We have successfully delivered more than 20,000 peptides of different purities, lengths, and site modifications.

Service Characteristics

Purity: from crude to 99% purity

Quantity: from milligram to gram

Length: up to 60 amino acids

Modifications: modifications at the N-terminal or the C-terminal site

One-stop service: from antigen design and synthesis to antibody preparation

Price: a special discount preparing more than 10 synthetic peptide antigens at one time

Modifications

As a manufacturer providing custom peptide synthesis services, we can prepare peptides with modifications and also produce site-specific antibodies.

N-terminal
{Ac}, Acetylation	{For}, Formylation	{Fmoc}, 9-Fluorenylmethyloxycarbonyl	{Mpa}, 3-Mercaptopropyl	{Z}, {CBZ}, Benzyloxycarbonyl
{Mal}, Maleimide, Maleoyl-b-Ala	MeOCO	{PEG1900}, PEG1900-NH-	Bz	{Glucose-}
{Boc}, tertbutoxycarbonyl	{Fructose-}	{Suc}, succinyl	DOTA	{MeO-Suc}
HYNIC-	Sebacic acid	minPEG~PEG5000	{But}, Butyric acid C4	{Lau}, Lauric acid C12
{Iba}, isobutyric acid C4	{Myr}, Myristic acid C14	{Hex}, Hexanoic acid C6	{Pal}, Palmitic acid C16	6-heptenoic acid C6
{Ste}, Stearic acid C18	{Oct}, Octanoic acid C8	Oleic Acid-	{Dec}, Decanoic acid C10

C-terminal
{-OH}, free acid group	-OEt (C-terminal)	{NH2}, Amidation	-OBzl (C-terminal)	{-CHO}, peptide aldehydes
-OtBu (C-terminal)	{-ol}, alcohol peptide	{-OSu}, hydroxysucinimide ester	{Cya}, Cysteamide	-NHMe (C-terminal)
{pNA}, p-nitroaniline	-NHEt (C-terminal)	{AMC},7-Amino-4-methylcoumarin	-NH(OMe)Me (C-terminal)	-OMe (C-terminal)

Protein coupling
BSA-Peptide N terminus	KLH-Peptide Cys	BSA-Peptide C terminus	OVA-Peptide N terminus	BSA-Peptide Cys
OVA-Peptide C terminus	KLH-Peptide N terminus	OVA-Peptide Cys	Cyclic peptide

Cyclic peptide
Mono Disulfide bridge	Same Seq. Inter-Disulfide bridge	Double Disulfide bridge	Different Inter-Disulfide bridg	Triple Disulfide bridge
Amide cyclic (end)	Random Triple Disulfide bridge	Amide cyclic (Side chain)

Epitope Prediction

BIC can accurately predict epitopes using linear prediction. We use different algorithms to analyze the hydrophilicity and surface accessibility of the protein sequences and then determine the antigenic determinants by comparing and analyzing the results of the different algorithms. The results are further reexamined to ensure their accuracy.

Chemical Peptide Synthesis Process

Related Services

If you need a synthetic peptide of size more than 60 amino acids, please select recombinant protein expression service.

If your synthetic peptide antigen is used to study antibodies, please select antibody preparation service.

If you need to analyze the interaction, please select biomolecular interaction analysis service.

Need more information? Please do not hesitate to get in touch.

Contact Us

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+1 (317) 703-0614

+1 (855) 427-1516