FGF19 (Fibroblast growth factor 19), Human Recombinant, E.coli

Fibroblast growth factors (FGFs) regulates developmental processes, such as brain patterning, branching morphogenesis and limb development. The Fibroblast growth factor 19 (FGF19) subfamily members of fibroblast growth factors, including FGF19, FGF21, and FGF23, is a novel group of endocrine factors that have been implicated in the regulation of many metabolic processes and regulate glucose, lipid, and energy homeostasis. FGF19 is a hormone-like enterokine released postprandially that emerged as a potential therapeutic agent for metabolic disorders, including diabetes and obesity. FGF19 transcripts are found in brain, cartilage, skin, retina, kidney, gall bladder and small intestine. Expression occurs primarily in the ileum from which the ligand circulates to the liver and carries out its main functions. FGF19 was stimulated after decreased adiposity, increased energy expenditure, reduced liver triglycerides, increased fatty acid oxidation, reduced glucose levels.